Unlocking the Protein Universe: Challenges and Innovations

Our research unit is dedicated to developing high-performance, specific, and sensitive methodologies for identifying, quantifying, and characterizing proteins, peptides, and other peptidomimetic molecules, such as toxins at the molecular level. Our primary goal is to decipher the secrets of the protein universe and contribute to a better understanding of biological mechanisms and human pathologies.

A Wide Range of Analytical Techniques
Our laboratory relies on cutting-edge expertise in mass spectrometry coupled with various separation and enrichment techniques. Key tools include MALDI-TOF/TOF MS detection, which is used for molecular mapping, tissue imaging, and archaeological screening. Nano-liquid chromatography (nanoLC) coupled with tandem mass spectrometry (MS/MS) offers increased sensitivity and precision for analyzing complex mixtures and identifying post-translational modifications.

Innovative Approaches for Multiple Applications
The unit develops innovative methodologies for protein analysis, addressing the analytical challenges posed by the complexity of biological samples and the limited amount of material available. Top-down, middle-down, and bottom-up analysis allows proteins to be studied at different levels of organization. Nano-liquid chromatographic techniques, either one-dimensional (LC-1D) or multidimensional (LC-2D), and peptide fragmentation by techniques such as CID, HCD, ETD, and UVPD contribute to the complete characterization of proteins and their modifications.

A Commitment to Innovation and Collaboration
The unit is committed to developing stable isotope labeling methods and strategies for obtaining qualitative and quantitative information on protein expression and post-translational modifications. Integrating microfluidics allows for increased sensitivity and reduced information loss during sample handling.

A Laboratory Facing the Future
Our constant commitment to research and innovation aims to advance the knowledge of the protein world and pave the way for new applications in fields such as medicine, biotechnology, and forensics. By sharing our discoveries and collaborating with the scientific community, we contribute to advancing science and developing solutions for the challenges of tomorrow.

Plateform of mass spectrometry and proteomics

Tribrid Orbitrap (Eclipse, Thermo)

The tribrid mass spectrometer (Eclipse ThermoFisher Scientific) was installed in November 2019. (...)

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Our 5800 has been moved to the new building safe and sound

The move went smoothly. However, it was necessary to dismantle the TOF, which would not fit (...)

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Proteomics@PSL University

Proteomics@PSL Development of analytical strategies and last-generation technologies for the (...)

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The lab is moving in its final location

At the end of April and beginning of May 2024, we will move into our new premises and leave the (...)

The lab moved in September 2019 in a temporary building

We have moved in a new dedicated building. Our new lab is now installed in Batiment K, just to (...)

Installation of autosampler Nanomate triversa!

The LTQ-FT ultra is now fully equipped with an autosampler Nanomate Advion that eases the (...)

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Publications 2011-2020

Potential of Fourier Transform Mass Spectrometry (Orbitrap and Ion Cyclotron Resonance) for... (...)

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